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JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable-Calbiochem
| 产品编号： | 4080425 |
| 规格： | The JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| 包装规格： | 2 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable-Calbiochem
H2N-YGRKKRRQRRR-RPKRPTTLNLF-NH2, TAT38-48 -Truncated Inhibitor based on JNK-Interacting Protein 1
基本信息
| Empirical Formula【经验(实验)分子式】 | C125H220N52O27 |
| Molecular weight | 2883.42 |
| General description【一般描述】 | The non-permeant JNK inhibitor peptide TI-JIP153-163 (Cat. No. 420133) is made cell-permeable with an N-terminal TAT protein transduction domain sequence. Shown to offer neuroprotection in a rat ischemic brain injury model in in vivo. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target JNK Product does not compete with ATP. Reversible: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂ |
| Physical form【外形】 | Supplied as a trifluoroacetate salt. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Guan, Q.H., et al. 2006. Neuroscience, 139, 609. Barr, R.K., et al. 2004. J. Biol. Chem.279, 36327. Bogoyevitch, M.A., et al. 2003. Cell. Mol. Biol. Lett.8, 550. Barr, R.K., et al. 2002. J. Biol. Chem.277, 10987. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | lyophilized |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| solubility【溶解性】 | water: 1 mg/mL DMSO: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 2 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
