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Wnt Agonist I in DMSO-CAS 853220-52-7-Calbiochem
| 产品编号： | 4080433 |
| 规格： | The Wnt Agonist I in DMSO, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications. |
| CAS NO： | 853220-52-7 |
| 包装规格： | 2 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4080433 | 2 MG | 1430 |
产品别名
853220-52-7
Wnt Agonist I in DMSO-CAS 853220-52-7-Calbiochem
Wnt Pathway Activator I in DMSO, 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine
2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I in DMSO
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H18N4O3 |
| Molecular weight | 350.37 |
| MDL number | MFCD09908087 |
| General description【一般描述】 | A cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3β (IC50 >60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells). Reported to cause substantial head defects during Xenopus embryonic development. The solid form of this compound (Cat. No. 681665) is also available. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Reversible: yes |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 25 mM (2 mg/228 µL) solution of Wnt Agonist I (Cat. No. 681665) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. |
| Other Notes【其他说明】 | Liu, J., et al. 2005. Angew. Chem. Int. Ed.44, 1987. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −70℃ |
| SMILES string | NC1=NC(NCC2=CC=C(OCO3)C3=C2)=CC(C4=CC=CC(OC)=C4)=N1 |
| packaging【包装】 | 2 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
