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InSolution PARP Inhibitor VIII, PJ34-Calbiochem
| 产品编号： | 4080568 |
| 规格： | The InSolution |
| 包装规格： | 2 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
InSolution PARP Inhibitor VIII, PJ34-Calbiochem
N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide, HCl, 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide, HCl
2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide, HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide, HCl
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H17N3O2 · xHCl |
| Molecular weight | 295.34 (free base basis) |
| MDL number | MFCD17014689 |
| General description【一般描述】 | A water-soluble phenanthridinone derivative that acts as a potent anti-inflammatory agent and a reversible inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC50 = 200 µM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 µM to 10 µM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC50 = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke. The solid form of this compound (Cat. No. 528150) is also available. A water-soluble phenanthridinone derivative that acts as a potent anti-inflammatory agent and a reversible inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC50 = 200 µM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 µM to 10 µM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC50 = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke. The solid form of this compound (Cat. No. 528151) is also available. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target PARP Reversible: yes |
| Warning【警告】 | Toxicity: Harmful (C) |
| Physical form【外形】 | A 20 mM (2 mg/301 µL) solution of PARP Inhibitor VIII, PJ34 (Cat. No. 528150) in H₂O. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. |
| Other Notes【其他说明】 | Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med.7, 255. Garcia-Soriano, F.G., et al. 2001. Nature Med.7, 108. Mabley, G.J., et al. 2001. Inflamm. Res.50, 561. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles protect from light |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −70℃ |
| SMILES string | O=C(CN(C)C)NC(C=C1)=CC(C2=C3C=CC=C2)=C1NC3=O |
| packaging【包装】 | 2 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
