您的位置：首页 > 产品中心 > 909910-43-6， 转化生长因子-βRI 激酶抑制剂 IV-CAS 909910-43-6-Calbiochem
转化生长因子-βRI 激酶抑制剂 IV-CAS 909910-43-6-Calbiochem
TGF-β RI Kinase Inhibitor IV-CAS 909910-43-6-Calbiochem
| 产品编号： | 4080903 |
| 规格： | TGF-β RI Kinase Inhibitor IV, CAS 909910-43-6, is a cell-permeable, selective inhibitor of ALK-4/5/7-mediated signaling (IC50 = 45, 12, and 7.5 nM, respectively). |
| CAS NO： | 909910-43-6 |
| 包装规格： | 2 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4080903 | 2 MG | 3010 |
产品别名
909910-43-6
转化生长因子-βRI 激酶抑制剂 IV-CAS 909910-43-6-Calbiochem
TGF-β RI Kinase Inhibitor IV-CAS 909910-43-6-Calbiochem
Transforming Growth Factor-β Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV
基本信息
| Empirical Formula【经验(实验)分子式】 | C25H19N5S |
| Molecular weight | 421.52 |
| General description【一般描述】 | A cell-permeable trisubstituted pyrazole compound that has been shown to selectively inhibit ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively, in luciferase transcription activity assays), but not ALK-1/2/3/6-mediated cellular signaling in Mv1Lu R4-2 transfectants expressing the individual Type I TGF-β receptors. Inhibits TGF-β-induced Smad2-phosphorylation in HaCaT cells and epithelial-to-mesenchymal transition in NMuMG cells at a concentration of 1 µM. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target IC50: 45, 12, and 7.5 nM, respectively, in inhibit ALK-4/5/7-mediated luciferase transcription activity assays Primary Target ALK-4/5/7 Product does not compete with ATP. Reversible: no |
| Warning【警告】 | Toxicity: Harmful (C) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Tojo, M., et al. 2005. Cancer Sci.96, 791. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | pale yellow |
| solubility【溶解性】 | DMSO: 20 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 2 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
