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抗-人IgG(Fc特异性)单克隆抗体

Anti-Human IgG (Fc specific)-Biotin antibody, Mouse monoclonal
产品编号:4081225
规格:clone HP-6017, purified from hybridoma cell culture
包装规格:0.2 ML,0.5 ML
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40812250.2 ML1560
40812250.5 ML2890
产品别名

抗-人IgG(Fc特异性)单克隆抗体

Anti-Human IgG (Fc specific)-Biotin antibody, Mouse monoclonal

Monoclonal Anti-Human IgG (Fc specific)

基本信息
NACRES
NA.46
General description【一般描述】
Immunoglobulin IgG is an abundant protein in human serum. The four classes of IgG include IgG1, IgG2, IgG3 and IgG4.. The IgG heavy chain region is mapped to human chromosome 14. Immunoglobulin super-family have a common structure, comprising of two heavy (H) chains and two light (L) chains, held together by disulfide linkages. The heavy chain has one variable N-terminal region and three to four constant (CH1-CH4) C-terminal regions. The L chain comprises of one variable N-terminal region and a constant C-terminal region.
Specificity【特异性】
该抗体对人 IgG 的 Fc 部分具有特异性,并识别所有人 IgG 亚类共有的表位。在 IUIS/WHO 研究中,该抗体被用作 Fc 特异性试剂。
Application【应用】
Anti-Human IgG (Fc specific) Biotin antibody, Mouse monoclonal has been used in fluoroimmunoassay of plasma samples.
Monoclonal Anti-Human IgG (Fc specific)-Biotin antibody produced in mouse is suitable for ELISA at a working dilution of 1:80,000. It was used for labeling mouse splenocytes and analysis by flow cytometry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Enzyme-linked immunosorbent assay (1 paper)
Biochem/physiol Actions【生化/生理作用】
IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections. The coupling of biotin to monoclonal Anti-Human IgG (Fc specific) antibody allows for the binding of various labels such as avidin or streptavidin.
IgG1 class is the most abundant and its deficiency results in hypogammaglobulinemia. IgG2 deficiency increases susceptibility to bacterial infections. IgG3 mediates effector functions, and IgG4 is associated with asymptomatic infection. Digestion of IgG by papain results in the generation of fragment antigen binding (Fab). Pepsin digestion of IgG generates fragment crystallisable (Fc). The Fc region of IgG antibody has enormous therapeutic potential and is exploited for the development of therapeutic antibodies.
Physical form【外形】
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
conjugate【偶联物】
biotin conjugate
antibody form【抗体形式】
purified immunoglobulin
antibody product type
secondary antibodies
clone【克隆】
HP-6017, monoclonal
form【形式】
buffered aqueous solution
species reactivity
sheep, horse (IgG), rabbit, goat, human
technique(s)
direct ELISA: 1:80,000
isotype【同位素/亚型】
IgG2a
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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