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Valproic Acid, Sodium Salt-CAS 1069-66-5-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4081630 | 5 G | 1190 |
产品别名
1069-66-5
Valproic Acid, Sodium Salt-CAS 1069-66-5-Calbiochem
2-Propylpentanoic Acid, Na
基本信息
| Empirical Formula【经验(实验)分子式】 | C8H15NaO2 |
| Molecular weight | 166.19 |
| MDL number | MFCD00078604 |
| NACRES | NA.77 |
| General description【一般描述】 | A cell-permeable, short-chained fatty acid that inhibits histone deacetylase activity (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 µM-1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates the ERK pathway, and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models. A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (0.35 mM - 1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates ERK pathway and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target HDAC1 Product does not compete with ATP. Reversible: no |
| Warning【警告】 | Toxicity: Harmful & Carcinogenic / Teratogenic (E) |
| Other Notes【其他说明】 | Gottlicher, M., et al. 2001. EMBO J.20, 6969. Knupfer, M.M., et al. 2001. Anticancer Res.21, 347. Phiel, C.J., et al. 2001. J. Biol. Chem.276, 36734. Vaden, D.L., et al. 2001. J. Biol. Chem.276, 15466. Yuan, P.X., et al. 2001. J. Biol. Chem.276, 31674. Chen, G., et al. 1999. J. Neurochem.72, 1327. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| potency【效能】 | 400 μM IC50 |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| color【颜色】 | white |
| solubility【溶解性】 | water: 50 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1 |
| InChI key | AEQFSUDEHCCHBT-UHFFFAOYSA-M |
| packaging【包装】 | 5 g in Plastic ampoule Packaged under inert gas |
安全信息
| Pictograms【象形图】 | GHS07,GHS08 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H361d |
| Precautionary Statements | P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Repr. 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
