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UBE2K human
产品别名
UBE2K human
Ubiquitin-conjugating enzyme E2-25K kDa
LIG
HYPG
Huntington interacting protein 2
HIP2
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | UBE2K, also known as UbcH1 or E2-25K, is an E2 (ubiquitin conjugating enzyme) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E3 enzymes. Once an E1 is carrying an activated ubiquitin in a ubiquitin-E1 thiolester complex, this activated ubiquitin is transferred to the active site cysteine of the E2 to form a ubiquitin-E2 thiolester complex. With the aid of an E3, the activated ubiquitin is then targeted to a specific substrate lysine. UBE2K is a biochemically important E2 due to its ability to form free K48-linked polyubiquitin chains in solution in the absence of an E3. This ability is attributed to UbcH1 possessing a C-terminal UBA domain, in addition to its E2 catalytic domain. UBE2K takes part in many cellular processes such as selective protein degradation, DNA repair, cell cycle control, and sporulation. In addition, UBE2K is involved in Alzheimer′s disease, Huntington′s disease and antigen processing through its interaction with amyloid-?, Huntington, and MHC-heavy chain proteins. |
| Physical form【外形】 | 75 μL of a 40 μM solution (3 nmoles) in TBS. |
| Preparation Note【制备说明】 | Centrifuge the vial prior to opening. |
产品性质
| biological source【生物来源】 | human |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | liquid |
| mol wt【分子量】 | 22.406 kDa |
| packaging【包装】 | pkg of 3 nmol |
| NCBI accession no.【NCBI登记号】 | P61086 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... UBE2K(3093) |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
