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Anti-IRS1 Antibody, clone AW58, rabbit monoclonal
| 产品编号： | 4082498 |
| 规格： | culture supernatant, clone AW58, Upstate® |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-IRS1 Antibody, clone AW58, rabbit monoclonal
insulin receptor substrate 1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Insulin Receptor substrate proteins are the effectors of both Insulin and IGF-initiated signaling. They share PH and PTB domains near their n-termini, and multiple Tyr phosphorylation motifs in their c-terminal regions. Proteins which bind to tyrosine-phosphorylated IRS-proteins include PI3 Kinase p85, GRB2, SHP2, Nck, Crk, and Fyn. IRS1 appears to be principally involved in IGF-signaling and cytoskeletal growth. IRS2 appears to be the critical mediator of Insulin signaling, as genetic ablation results in type II diabetes. IRS3 is expressed primarily in adipocytes and is an unusually potent activator of PI3 Kinase. IRS4 lacks the tyrosine residues which in the other IRS-proteins binds to SHP2. |
| Specificity【特异性】 | IRS1 |
| Immunogen【免疫原】 | Peptide corresponding to carboxy-terminal 14 amino acids (C-YASINFQKQPEDRQ) of rat liver IRS1 |
| Application【应用】 | Research Category Signaling Anti-IRS1 Antibody, clone AW58 detects level of IRS1 & has been published & validated for use in IP & WB. Immunoblot Analysis: 1:1,000 to 1:4,000 dilutions of this lot detected IRS1 in RIPA lysates from 3T3/A31 mouse fibroblasts. Immunoprecipitation: 5-10μl of this lot immunoprecipitated IRS1 from 500μg of 3T3/A31 RIPA lysate. Research Sub Category Insulin/Energy Signaling |
| Quality【质量】 | routinely evaluated by immunoblot on in RIPA lysates from 3T3/A31 mouse fibroblasts |
| Linkage【联系】 | Replaces: 05-784 |
| Physical form【外形】 | Cultured supernantant in 0.05% sodium azide |
| Legal Information【法律信息】 | UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | culture supernatant |
| antibody product type | primary antibodies |
| clone【克隆】 | AW58, monoclonal |
| species reactivity | human, mouse, rat |
| manufacturer/tradename | Upstate® |
| technique(s) | immunoprecipitation (IP): suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG |
| NCBI accession no.【NCBI登记号】 | NM_005544 |
| UniProt accession no.【UniProt登记号】 | P35568 |
| shipped in【运输】 | dry ice |
| Gene Information | human ... IRS1(3667) |
产品说明
| Target description【目标描述】 | Mr ~145-165kDa |
| Storage and Stability【储存及稳定性】 | 1 year at -20°C from date of shipment |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
