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Anti-RalB Antibody, clone 25
产品别名
Anti-RalB Antibody, clone 25
RAS-like protein B, v-ral simian leukemia viral oncogene homolog B, GTP binding protein, v-ral simian leukemia viral oncogene homolog B
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | RalA and RalB are Ras-family small monomeric GTPases that can be activated through a Ras-dependent mechanism. The two are highly homologous (89%). RalA is required for anchorage-independent proliferation and tumorigeneisis by driving exocyst assembly and polarizatied exocystossis in epithelaial cells (Cascone, 2008). RalB is required for metastatic formation and cell survival by driving exocyst assembly during polarized cell migration (Cascone, 2008). Ral proteins are proximal effectors of oncogenic Ras and their activity is needed to support tumorigenesis in certain cancers. Mutants of Ras that are defective in activating all known Ras effectors except Ral GEF are still able to induce invasive phenotypes in transfected cells, suggesting a role for Ral in these processes |
| Specificity【特异性】 | Other species have not been tested. This antibody is specific for RalB and does not detect RalA. |
| Immunogen【免疫原】 | Synthetic peptide of the C-terminus of RalB Epitope: C-terminus |
| Application【应用】 | Research Sub Category Cytoskeletal Signaling G-proteins Research Category Signaling Detect RalB using this Anti-RalB Antibody, clone 25 validated for use in WB. |
| Quality【质量】 | Evaluated by western blot on HEK293 or NIH/3T3 cell lysates. Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect RalB in HEK293, NIH/3T3, and rat liver cell lysate. |
| Physical form【外形】 | Format: Purified Purified mouse monoclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Protein G Purified |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Legal Information【法律信息】 | UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | 25, monoclonal |
| species reactivity | mouse, human, rat |
| manufacturer/tradename | Upstate® |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NM_002881.2 |
| UniProt accession no.【UniProt登记号】 | P11234 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... RALB(5899) |
产品说明
| Target description【目标描述】 | 24 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8ºC from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
