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Anti-NSD1 Antibody, clone 1NW-1A10
| 产品编号： | 4082601 |
| 规格： | ascites fluid, clone 1NW-1A10, from mouse |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-NSD1 Antibody, clone 1NW-1A10
Androgen receptor-associated coregulator 267, Lysine N-methyltransferase 3B, NR-binding SET domain-containing protein, Nuclear receptor-binding SET domain-containing protein 1, Sotos syndrome, nuclear receptor binding SET domain protein 1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | NSD1 (also known as KMT3B) is a histone methyltransferase shown to methylate lysine 36 of histone H3 and lysine 20 of histone H4. NSD1 is a described as an intermediary transcription factor and depending on its cellular context, it is able to either negatively or positively influence transcription. Expression of this gene has been described in skeletal muscles, kidneys, adult and fetal brain, thymus and spleen. Heterozygous mutations and deletions of the NSD1 gene are associated with Sotos Syndrome, an autosomal dominant condition characterized by macrocephaly, tall stature, facial elongation, accelerated bone aging, and mental retardation. |
| Specificity【特异性】 | This antibody recognizes NSD1. |
| Immunogen【免疫原】 | Recombinant protein corresponding to mouse NSD1. Epitope: Unknown |
| Application【应用】 | Used for immunohistochemistry on paraffin sections in Visser et al., (2012). Used for fluorescent immunocytochemistry in Huang et al.,(1998). Anti-NSD1 Antibody, clone 1NW-1A10 is a mouse monoclonal antibody for detection of NSD1, also known as &rogen receptor-associated coregulator 267, Lysine N-methyltransferase 3B, has been validated in WB. Research Sub Category Histone Modifying Proteins Chromatin Biology Research Category Epigenetics & Nuclear Function Epigenetics & Nuclear Function |
| Quality【质量】 | Evaluated by Western Blot in PC12 cell lysate. Western Blot Analysis: 1:1,000 dilution of this antibody detected NSD1 on 10 µg of PC12 cell lysate. |
| Physical form【外形】 | Unpurified Unpurified mouse monoclonal IgG1κ in preservative-free ascites. |
| Analysis Note【分析说明】 | Control PC12 cell lysate |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | ascites fluid |
| antibody product type | primary antibodies |
| clone【克隆】 | 1NW-1A10, monoclonal |
| species reactivity | rat |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable immunofluorescence: suitable immunohistochemistry: suitable (paraffin) western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_032765.3 |
| UniProt accession no.【UniProt登记号】 | O88491 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~ 300 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
