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Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W, rabbit monoclonal
| 产品编号： | 4082614 |
| 规格： | culture supernatant, clone A11W, from rabbit |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W, rabbit monoclonal
signal transducer and activator of transcription 5A, signal transducer and activator of transcription 5B, transcription factor STAT5B
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | The STAT proteins (signal transducer and activator of transcription) comprise a family of transcription factors. STATs are activated through tyrosine phosphorylation, mainly by JAK kinases, which results in their dimerization, nuclear translocation and regulation of gene expression. STAT5 activity is induced by numerous cytokines and growth factors. While STAT5A and STAT5B share 96% amino acid homology, the two isoforms have distinct physiological functions. Phosphorylation of tyrosine 694/699 is a key marker of STAT5A/B activation. |
| Specificity【特异性】 | Phospho-STAT5A/B (Tyr694/699). |
| Immunogen【免疫原】 | Epitope: pTyr694/699 KLH-conjugated, synthetic peptide containing the sequence DGpYVK in which pY corresponds to phospho-tyrosine at residue 694 of human STAT5A or residue 699 of STAT5B. |
| Application【应用】 | Research Sub Category Transcription Factors Detect phospho-STAT5A/B (Tyr694/699) using this Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W validated for use in WB. Research Category Signaling Apoptosis & Cancer |
| Quality【质量】 | Evaluated by western blot on RIPA lysates from 3T3/NIH cells untreated and treated with PDGF. Western Blot Analysis: A 1:1,000-1:2,000 dilution of this antibody detected phospho-STAT5A/B (Tyr694/699) in lysates from 3T3/NIH cells treated with PDGF. |
| Linkage【联系】 | Replaces: 05-886 |
| Physical form【外形】 | Cultured supernatant containing 0.05% sodium azide. |
| Analysis Note【分析说明】 | Control PDGF treated 3T3/NIH cells |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | culture supernatant |
| antibody product type | primary antibodies |
| clone【克隆】 | A11W, monoclonal |
| species reactivity | rat, human, chimpanzee, bovine, mouse |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgG |
| suitability【适用性】 | not suitable for immunoprecipitation |
| NCBI accession no.【NCBI登记号】 | NM_003152 NM_012448 |
| UniProt accession no.【UniProt登记号】 | P42229 |
| shipped in【运输】 | dry ice |
产品说明
| Target description【目标描述】 | ~95 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
