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NS309-CAS 18711-16-5-Calbiochem
产品编号: | 4083584 |
规格: | A potent activator of Ca2+ -activated K+ channels of SK and IK types, but not BK type channels. It is at least 1000 times more potent than 1-EBIO. |
CAS NO: | 18711-16-5 |
包装规格: | 10 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4083584 | 10 MG | 1380 |
产品别名
18711-16-5
NS309-CAS 18711-16-5-Calbiochem
Ca2+ -activated K+ Channels Activator, NS309, NS-309, NS 309
基本信息
Empirical Formula【经验(实验)分子式】 | C8H4Cl2N2O2 |
Molecular weight | 231.04 |
MDL number | MFCD06798346 |
General description【一般描述】 | A potent activator of Ca2+ -activated K+ channels of SK and IK types but not BK type channels. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell. NS309 blocks L-type Calcium channels with IC50 = 10 µM/L. Recently, this compound has been shown to produce endothelium-dependent hyperpolarizations in guinea pig carodid arteries by opening KCa2.3 and KCa3.1 channels demonstrating a new therapeutic option for treating hypertension. Please note that the molecular weight for this compound is batch-specific due to variable water content. A potent activator of Ca2+ -activated K+ channels of SK and IK types but not BK type channels. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell. NS309 blocks L-type Calcium channels with IC50 = 10 µM/L. Recently, this compound has been shown to produce endothelium-dependent hyperpolarizations in guinea pig carodid arteries by opening KCa2.3 and KCa3.1 channels demonstrating a new therapeutic option for treating hypertension. |
Biochem/physiol Actions【生化/生理作用】 | Primary Target Ca2+-activated K+ channels |
Warning【警告】 | Toxicity: Standard Handling (A) |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
Other Notes【其他说明】 | Leurangue, V. et al. 2008. Naunyn Schmiedebergs Arch. Pharmacol.377, 101. Morimura, K. et al. 2006. J. Pharmacol. Sci.100, 237. Strobaek, D. et al. 2004. Biochim. Biophys. Acta.1665, 1. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | yellow |
solubility【溶解性】 | DMSO: 100 mM |
storage temp.【储存温度】 | −20℃ |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 2 |