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InSolution (+)-Brefeldin A, Eupenicillium brefeldianum-CAS 20350-15-6-Calbiochem
| 产品编号： | 4083674 |
| 规格： | A 25 mM solution of (+)-Brefeldin A in DMSO. |
| CAS NO： | 20350-15-6 |
| 包装规格： | 2 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083674 | 2 MG | 1860 |
产品别名
20350-15-6
InSolution (+)-Brefeldin A, Eupenicillium brefeldianum-CAS 20350-15-6-Calbiochem
1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one, (1 S,2 E,7 S,10 E,12 R,13 R,15 S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one,
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H24O4 |
| Molecular weight | 280.36 |
| MDL number | MFCD12913297 |
| General description【一般描述】 | Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target ADP-ribosylation factor (ARF) Reversible: yes |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 25 mM (2 mg/285 µL) solution of (+)-Brefeldin A (Cat. No. 203729) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions prior to use. |
| Other Notes【其他说明】 | Yamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA97, 2567. Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA93, 12856. Mendez, A.J. 1995. J. Biol. Chem.270, 5891. Ridgway, N.D., et al. 1995. J. Biol. Chem. 270, 8023. Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA91, 3063. Ktistakis, N.Y., et al. 1992. Nature356, 344. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
| storage temp.【储存温度】 | −70℃ |
| InChI | 1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15-/m0/s1 |
| InChI key | KQNZDYYTLMIZCT-PNFJWZTBSA-N |
| packaging【包装】 | Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (refers to pure substance) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (refers to pure substance) |
