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Telomerase Inhibitor X, BIBR1532-CAS 321674-73-1-Calbiochem
产品编号: | 4083748 |
规格: | A cell-permeable, selective, highly potent, non-nucleotide competitive inhibitor of telomerase activity (IC50 = 93 nM in HeLa cells nuclear extracts). |
CAS NO: | 321674-73-1 |
包装规格: | 10 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4083748 | 10 MG | 2770 |
产品别名
321674-73-1
Telomerase Inhibitor X, BIBR1532-CAS 321674-73-1-Calbiochem
BIBR 1532, BIBR-1532
基本信息
Empirical Formula【经验(实验)分子式】 | C21H17NO3 |
Molecular weight | 331.36 |
General description【一般描述】 | A cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC50 = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner. A cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC50 = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner. Please note that the molecular weight for this compound is batch-specific due to variable water content. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target Teomerase Reversible: yes |
Warning【警告】 | Toxicity: Standard Handling (A) |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
Other Notes【其他说明】 | Damm, K., et al. 2001. The. EMBO J.20, 6958. Pascolo, E., et al. 2002. J. Biol. Chem.277,15566. Nakashima, M., et al. 2013. J. Biol. Chem.288, 33171. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | solid |
potency【效能】 | 93 nM IC50 |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | off-white |
solubility【溶解性】 | DMSO: 100 mg/mL |
storage temp.【储存温度】 | 2-8℃ |
packaging【包装】 | Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |