Casein Kinase II Inhibitor III, TBCA-CAS 934358-00-6-Calbiochem

C₉H₄Br₄O₂

463.74

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀ = 110 nM, K_i = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC₅₀ = 7.7 µM). Also available as a 25 mM solution in DMSO (Cat. No. 218861).
A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀ = 110 nM, K_i = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC₅₀ = 7.7 µM).

Cell permeable: yes
Target K_i: 77 nM against Casein Kinase II
Reversible: no
Product competes with ATP.

Toxicity: Irritant (B)

Pagano, M.A., et al. 2006. Chembiochem8, 129

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

110 nM IC₅₀

Calbiochem^®

OK to freeze
protect from light

off-white

DMSO: 10 mg/mL (Use only fresh DMSO.)
ethanol: 5 mg/mL

ambient

2-8℃

5 mg in Plastic Bag(s)
Packaged under inert gas