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JNK Inhibitor VIII-CAS 894804-07-0-Calbiochem
| 产品编号： | 4083768 |
| 规格： | The JNK Inhibitor VIII, also referenced under CAS 894804-07-0, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| CAS NO： | 894804-07-0 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
894804-07-0
JNK Inhibitor VIII-CAS 894804-07-0-Calbiochem
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H20N4O4 |
| Molecular weight | 356.38 |
| General description【一般描述】 | A cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC50 of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target Ki: 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively Product competes with ATP. Reversible: yes |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Other Notes【其他说明】 | Vivanco, I., et al. 2007. Cancer Cell11, 555. Szczepankiewicz, B. G., et al. 2006. J. Med. Chem.49, 3563. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | brown |
| solubility【溶解性】 | DMSO: 10 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
