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eIF-2α Inhibitor II, Sal003-CAS 301359-91-1-Calbiochem
| 产品编号： | 4083834 |
| 规格： | The eIF-2α Inhibitor II, Sal003, also referenced under CAS 301359-91-1, controls the biological activity of eIF-2α. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| CAS NO： | 301359-91-1 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
301359-91-1
eIF-2α Inhibitor II, Sal003-CAS 301359-91-1-Calbiochem
3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide, Sal003
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H15Cl4N3OS |
| Molecular weight | 463.21 |
| General description【一般描述】 | A cell-permeable Salubrinal (Cat. No. 324895) analog that is reported to be more potent and soluble than Salubrinal. In addition to being a useful tool in studying elF2α-mediated cellular processes in cultures in vitro, enhanced elF2α phosphorylation by Sal003 treatment in the brain (40 pmol per animal) is shown to impair long-term memory in mice in vivo. A cell-permeable Salubrinal (Cat. No. 324895) analog that is reported to be more potent and soluble than Salubrinal. In addition to being a useful tool in studying elF2α-mediated cellular processes in cultures in vitro, enhanced elF2α phosphorylation by Sal003 treatment in the brain (40 pmol per animal) is shown to impair long-term memory in mice in vivo. |
| Warning【警告】 | Toxicity: Regulatory Review (Z) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Raven, J.F., et al. 2008. J. Biol. Chem.283, 3097. Baltzis, D., et al. 2007. J. Biol. Chem.282, 31675. Kazemi, S., et al. 2007. Mol. Biol. Cell18, 3635. Costa-Mattioli, M., et al. 2007. Cell129, 195. Robert, F., et al. 2006. Mol. Biol. Cell17, 4632. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | off-white |
| solubility【溶解性】 | DMSO: 10 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
