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HSP90 Inhibitor, CCT018159-CAS 171009-07-7-Calbiochem
| 产品编号： | 4083864 |
| 规格： | The HSP90 Inhibitor, CCT018159, also referenced under CAS 171009-07-7, controls the biological activity of HSP90. |
| CAS NO： | 171009-07-7 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
171009-07-7
HSP90 Inhibitor, CCT018159-CAS 171009-07-7-Calbiochem
4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H20N2O4 |
| Molecular weight | 352.38 |
| General description【一般描述】 | A cell-permeable pyrazoloresorcinol compound that inhibits HSP90 ATPase activity (IC50 = 3.2 µM and 6.6 µM against human HSP90β and yeast HSP90, respectively) by targeting the enzyme′s N-terminal ATP binding site. It exhibits no detectable effects against human Hsp70 or topoisomerase II even at concentrations as high as 100 µM and inhibits a panel of 20 commonly studied kinases only at much higher concentrations. Unlike 17-AAG (Cat. No. 100068), the antitumor activity of CCT018159 is not affected by the expression of NQ01/DT-diaphorase or P-glycoprotein. |
| Warning【警告】 | Toxicity: Irritant (B) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solution are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Hardcastle, A., et al. 2007. Mol. Cancer Ther.6, 1112. Sharp, S.Y., et al. 2007. Cancer Res.67, 2206. Smith, N.F., et al. 2006. Mol. Cancer Ther.5, 1628. Dymock, B.W., et al. 2005. J. Med. Chem.48, 4212. Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett.15, 3338. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | water: 1.7 mg/mL DMSO: 35 mg/mL ethanol: 35 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
