Hydroxyurea-CAS 127-07-1-Calbiochem

CH₄N₂O₂

76.05

MFCD00007943

NA.77

Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.

Primary Target
Inhibiting ribonucleotide reductase
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Toxicity: Carcinogenic / Teratogenic (D)

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.

Leyden, D., et al. 2000. Anticancer Res.20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze

white

water: 5 mg/mL

ambient

2-8℃

1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)

VSNHCAURESNICA-UHFFFAOYSA-N

5 g in Plastic ampoule

GHS08

Danger

H340 - H361

P201 - P202 - P280 - P308 + P313 - P405 - P501

Muta. 1B - Repr. 2

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 3