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InSolution AG490-Calbiochem
产品别名
InSolution AG490-Calbiochem
JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H14N2O3 |
| Molecular weight | 294.30 |
| General description【一般描述】 | Potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). Jak family tyrosine kinase inhibitor. Inhibition of Jak2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal haematopoiesis. Inhibits the constitutive activation of STAT-3 and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. Also reported to inhibit guanylyl cyclase. |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658401) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-70°C). Once opened, stock solution is stable for up to 6 months at -70°C. |
| Other Notes【其他说明】 | Jaleel, M., et al. 2004. Biochemistry43, 8247. Eriksen, K.W., et al. 2001. Leukemia15, 787. Kirken, R.A., et al. 1999. Leukoc. Biol.65, 891. Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764. Meydan, N., et al. 1996. Nature 379, 645. Gazit, A., et al. 1991. J. Med. Chem.34, 1896. Levitzki, A. 1990. Biochem. Pharmacol.40, 913. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −70℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 3 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (Dimethylsulfoxide) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (Dimethylsulfoxide) |
