InSolution Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor-CAS 509093-47-4-Calbiochem

C₂₀H₂₁N₅O₄

395.41

MFCD09752602

A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC₅₀ = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC₅₀ >10 µM), including lck and src. The solid form of this compound (Cat. No. 407601) is also available.

Primary Target
IRAK-1/4
Target IC₅₀: 300 nM and 200 nM for IRAK-1 and -4
Reversible: yes

Toxicity: Irritant (B)

A 25 mM (5 mg/506 µL) solution of Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor (Cat. No. 407601) in DMSO.

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Srivastava, R., et al. 2012. Cancer Res.72, In press.
Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol.293, G429.
Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett.16, 2842.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

liquid

Calbiochem^®

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

dry ice

−70℃

5 mg in Glass bottle
Packaged under inert gas

10 - Combustible liquids

WGK 2

188.6 °F - (refers to pure substance)

87 ℃ - (refers to pure substance)