CGP-37157-CAS 75450-34-9-Calbiochem

C₁₅H₁₁Cl₂NOS

324.22

MFCD09055422

A cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na⁺/Ca²⁺ exchanger (IC₅₀ = 360 nM). Enhances the export of Ca²⁺ from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca²⁺ channels.

Cell permeable: yes
Target IC₅₀: 360 nM against mitochondrial Na+/Ca2+ exchanger
Product does not compete with ATP.
Reversible: no
Primary Target
Mitochondrial Na+/Ca2+ exchanger

Toxicity: Standard Handling (A)

Dilute in Ca²⁺-free buffer just prior to use.

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Jornot, L., et al. 1999. J. Cell Sci.112, 1013.
Babcock, D.F., et al. 1997. J. Cell Biol.136, 833.
Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol.340, 295.
Griffiths, E.J., et al. 1997. Cell Calcium21, 321.
White, R.J., and Reynolds, I.J. 1996, J. Neurosci.16, 5688.
Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol.21, 595.
Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem.268, 938.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

white

DMSO: 5 mg/mL

ambient

2-8℃

1S/C15H11Cl2NOS/c16-9-5-6-13-11(7-9)15(20-8-14(19)18-13)10-3-1-2-4-12(10)17/h1-7,15H,8H2,(H,18,19)

KQEPIRKXSUIUTH-UHFFFAOYSA-N

5 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3