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COX-2 Inhibitor V, FK3311-CAS 116686-15-8-Calbiochem
| 产品编号： | 4084022 |
| 规格： | The COX-2 Inhibitor V, FK3311, also referenced under CAS 116686-15-8, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications. |
| CAS NO： | 116686-15-8 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4084022 | 5 MG | 3350 |
产品别名
116686-15-8
COX-2 Inhibitor V, FK3311-CAS 116686-15-8-Calbiochem
4'-Acetyl-2'-(2,4-Difluorophenoxy)methanesulfonanilide
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H13F2NO4S |
| Molecular weight | 341.33 |
| General description【一般描述】 | A cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC50 = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC50 = 160 µM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung in vivo. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Otani, Y., et al. 2007. J. Invest. Surg.20, 175. Sunose, Y., et al. 2001. Transplant Proc.33, 862. Grossman, C.J., et al. 1995. Inflamm. Res.44, 253. Nakamura, K., et al. 1993. Chem. Pharm. Bull.41, 2050. Tsuji, K., et al. 1992. Chem. Pharm. Bull.40, 2399. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | ethanol: 15 mg/mL DMSO: 30 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C15H13F2NO4S/c1-9(19)10-3-5-13(18-23(2,20)21)15(7-10)22-14-6-4-11(16)8-12(14)17/h3-8,18H,1-2H3 |
| InChI key | DIIYLGZNZGPXRR-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
