您的位置：首页 > 产品中心 > 54-21-7， Sodium Salicylate-CAS 54-21-7-Calbiochem
Sodium Salicylate-CAS 54-21-7-Calbiochem
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4084150 | 5 G | 889 |
产品别名
54-21-7
Sodium Salicylate-CAS 54-21-7-Calbiochem
Salicylic Acid, Na, NaSal
基本信息
| Empirical Formula【经验(实验)分子式】 | C7H5O3 · Na |
| Molecular weight | 160.10 |
| MDL number | MFCD00002440 |
| General description【一般描述】 | A non-steroidal, anti-inflammatory drug that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation. A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases Product does not compete with ATP. Reversible: no |
| Warning【警告】 | Toxicity: Harmful (C) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Schwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78. Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907. Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869. Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585. Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (titration) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| color【颜色】 | off-white |
| solubility【溶解性】 | water: 50 mg/mL ethanol: soluble |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 10-30℃ |
| InChI | 1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1 |
| InChI key | ABBQHOQBGMUPJH-UHFFFAOYSA-M |
| packaging【包装】 | 5 g in Glass bottle Packaged under inert gas |
安全信息
| Pictograms【象形图】 | GHS07,GHS08 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H319 - H361d |
| Precautionary Statements | P201 - P202 - P264 - P301 + P312 - P305 + P351 + P338 - P308 + P313 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 208.9 °F - Pensky-Martens closed cup |
| Flash Point(C)【闪点(C)】 | 98.3 ℃ - Pensky-Martens closed cup |
