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TMEM16A Inhibitor, T16Ainh-A01-Calbiochem

产品编号:4084154
规格:The TMEM16A Inhibitor, T16Ainh-A01 controls the biological activity of TMEM16A.
CAS NO:552309-42-9
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40841545 MG3280
产品别名

552309-42-9

TMEM16A Inhibitor, T16Ainh-A01-Calbiochem

ANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01

基本信息
Empirical Formula【经验(实验)分子式】
C19H20N4O3S2
Molecular weight
416.52
MDL number
MFCD03278952
General description【一般描述】
An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 µM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels.
Warning【警告】
Toxicity: Standard Handling (A)
Reconstitution【重悬】
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes【其他说明】
Davis, A.J., et al. 2012 Br. J. Pharmacol.,in press
Namkung, W., et al. 2011., J Biol Chem. in press.
Namkung, W., et al. 2011., FASEB J. in press.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥97% (HPLC)
form【形式】
powder
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
protect from light
color【颜色】
off-white
solubility【溶解性】
DMSO: 100 mg/mL, clear, colorless
shipped in【运输】
ambient
storage temp.【储存温度】
2-8℃
packaging【包装】
5 mg in Glass bottle
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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