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TOFA-CAS 54857-86-2-Calbiochem
| 产品编号： | 4084155 |
| 规格： | A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. |
| CAS NO： | 54857-86-2 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4084155 | 5 MG | 4920 |
产品别名
54857-86-2
TOFA-CAS 54857-86-2-Calbiochem
5-(Tetradecyloxy)-2-furoic acid
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H32O4 |
| Molecular weight | 324.45 |
| MDL number | MFCD01726059 |
| General description【一般描述】 | A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells. A cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effects of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells. |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target Acetyl-CoA carboxylase (ACC) Target IC50: 4 µM inhibiting cellular fatty acid synthesis in human breast cancer cell line MCF7 Reversible: yes Cell permeable: yes Product competes with ATP. |
| Warning【警告】 | Toxicity: Carcinogenic / Teratogenic (D) |
| Preparation Note【制备说明】 | Slight warming and sonication may be required for complete solubilization in ethanol. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Landree, L.E., et al. 2004. J. Biol. Chem.279, 3817. Zhou, W., et al. 2003. Cancer Res.63, 7330. Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA100, 12624. Pizer, E.S., et al. 2000. Cancer Res.60, 213. Arbeeny, C.M., et al. 1992. J. Lipid Res.33, 843. Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res.25, 831. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | off-white |
| solubility【溶解性】 | DMSO: 10 mg/mL ethanol: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21) |
| InChI key | CZRCFAOMWRAFIC-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
