Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor-CAS 509093-47-4-Calbiochem

C₂₀H₂₁N₅O₄

395.41

A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC₅₀ = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC₅₀ >10 µM), including lck and src. Also available as a 25 mM solution in DMSO (Cat. No. 407602).
A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC₅₀ = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC₅₀ >10 µM), including lck and src.

Cell permeable: yes
Primary Target
Interleukin-1 receptor-associated kinases
Target IC₅₀: 300 nM and 200 nM for IRAK-1 and -4
Product does not compete with ATP.
Reversible: no

Toxicity: Harmful (C)

Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol.293, G429.
Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett.16, 2842.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

crystalline solid

Calbiochem^®

OK to freeze
protect from light

yellow

DMSO: 10 mg/mL

ambient

−20℃

5 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3