IKK-2 Inhibitor V-CAS 978-62-1-Calbiochem

C₁₅H₈ClF₆NO₂

383.67

MFCD00218820

A cell-permeable salicylamide compound that acts as an IKK-2 inhibitor by selectively blocking IκBα phosphorylation (IC₅₀ ~ 250 nM) and thereby prevents the induction of NF-κB p65 nuclear translocation. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC₅₀<1 µM) in cardiomyocytes, and ameliorate insulin resistance in KKA_y mice by regulating adiponectin release.
A cell-permeable IKK-2 inhibitor that selectively blocks IκBα phosphorylation (IC₅₀ ~250 nM) and prevents the induction of NF-κB p65 nuclear translocation. Reported to suppress neoplastic proliferation of mast cells with constitutively activated c-kit receptor. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC₅₀<1 µM) in cardiomyocytes, and ameliorate insulin resistance in diabetic KKA_y mice by regulating adiponectin release.

Cell permeable: yes
Primary Target
IKK-2
Product does not compete with ATP.
Reversible: no
Target IC₅₀: ~ 250 nM blocking IκBα phosphorylation

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Kamon, J., et al. 2004. Biochem. Biophys. Res. Commun.323, 242.
Onai, Y., et al. 2004. Cardiovasc. Res.63, 51.
Tanaka, A., et al. 2004. Blood105, 2324.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

white

ethanol: 1 mg/mL
DMSO: 5 mg/mL

ambient

2-8℃

5 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3