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Interleukin-12 human
| 产品编号： | 4084468 |
| 规格： | ≥97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture |
| 包装规格： | 5 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Interleukin-12 human
IL-12
基本信息
| MDL number | MFCD00212975 |
| NACRES | NA.32 |
| Biochem/physiol Actions【生化/生理作用】 | Interleukin-12 (IL-12) was identified as a factor secreted by human Epstein-Barr (EBV)-transformed B cell lines. IL-12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL-12 is produced predominantly by monocytes and NK cells and induces T cells and NK cells to produce IFN-γ. Human IL-12 is not active on mouse cells, but murine IL-12 is active on both murine and human lymphocytes. The biological activity of recombinant human IL-12 was measured by its ability to stimulate the proliferation of PHA-activated human T lymphoblasts. IL-12 has anti-angiogenic properties. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in baculovirus infected Sf21 cells |
| Assay【测定】 | ≥97% (SDS-PAGE and N-terminal analysis) |
| form【形式】 | lyophilized powder |
| potency【效能】 | 0.01-0.05 ng/mL ED50 |
| mol wt【分子量】 | glycoprotein 75 kDa |
| packaging【包装】 | pkg of 5 μg |
| technique(s) | cell culture | mammalian: suitable |
| impurities【杂质】 | endotoxin, tested |
| UniProt accession no.【UniProt登记号】 | P29459, P29460 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IL12A(3592), IL12B(3593) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
