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Anti-EZH2 Antibody, clone BD43
产品别名
Anti-EZH2 Antibody, clone BD43
Enhancer of zeste homolog 2, Lysine N-methyltransferase 6, enhancer of zeste 2, enhancer of zeste homolog 2, ENX-1
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | EZH2 (enhancer of zeste homologue 2), also known as Enx1, is a member of the polycomb group of proteins and is involved in cell cycle regulation. EZH2 represses transcription via trimethylation of histone H3 on Lys27 (H3K27) as indicated by the fact that RNAi-mediated knockdown of EZH2 resulted in a loss of H3K27 trimethylation. EZH2 is ubiquitously expressed during early embryo genesis, and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. In the adult, EZH2 is restricted to the spleen, testis and placenta. EZH2 and BMI-1 genes are coexpressed in Reed-Sternberg cells of Hodgkin’s disease. Coexpression of BMI-1 and EZH2 is also associated with cycling cells and degree of malignancy in B-cell non-Hogkin’s lymphoma. EZH2 is involved in the progression of prostate cancer, and has been identified as a marker of aggressive breast cancer. Two transcript variants encoding distinct isoforms have been identified for this gene |
Specificity【特异性】 | This antibody recognizes human EZH2 (~98kDa). Not tested in other species. |
Immunogen【免疫原】 | Recombinant fusion protein of amino acids 1-286 of human EZH2 tagged with MBP. |
Application【应用】 | Research Category Epigenetics & Nuclear Function Apoptosis & Cancer Research Sub Category Chromatin Biology Use Anti-EZH2 Antibody, clone BD43 (Mouse Monoclonal Antibody) validated in WB to detect EZH2 also known as Lysine N-methyltransferase 6, enhancer of zeste homolog 2, ENX-1. |
Quality【质量】 | Western Blot Analysis: 1:5,000 from a previous lot detected EZH2 of HeLa Nuclear extract. |
Linkage【联系】 | Replaces: 04-1047 |
Physical form【外形】 | Purified immunoglobulin in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G Purified |
Analysis Note【分析说明】 | Control HeLa Nuclear Extracts |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | BD43, monoclonal |
species reactivity | mouse, human |
technique(s) | western blot: suitable |
isotype【同位素/亚型】 | IgG1κ |
NCBI accession no.【NCBI登记号】 | NP_004447.2 |
UniProt accession no.【UniProt登记号】 | Q15910 |
shipped in【运输】 | wet ice |
Gene Information | human ... EZH2(2146) |
产品说明
Target description【目标描述】 | ~98 kDa |
Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |