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Erasin
产品别名
Erasin
(E)-N′-((6-(tert-butyl)-4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
Erlotinib-resistance antagonizing STAT3 inhibitor
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H19N3O3 |
| Molecular weight | 349.38 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Erasin (Erlotinib-resistance antagonizing STAT3 inhibitor) is a selective inhibitor of STAT3 with selectivity over STAT5 and STAT1 in cell-based assays. It was shown to increase the apoptotic rate of HCC-827 cells with acquired resistance against Erlotinib in addition to increasing the apoptotic rate of cultured NSCLC cells in a STAT3-dependent manner. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C1C(/C=N/NC(C2=CC=CN=C2)=O)=COC3=CC=C(C(C)(C)C)C=C31 |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
