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HET0016
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4086170 | 5 MG | 883 | |||
| 4086170 | 25 MG | 3100 |
产品别名
339068-25-6
HET0016
N-(4-Butyl-2-methylphenyl)-N′-hydroxymethanimidamide
N-Hydroxy-N′-(4-n-butyl-2-methylphenyl)formamidine
HET 0016
N-(4-Butyl-2-methylphenyl)-N′-hydroxyformamidine
HET-0016
N′-(4-Butyl-2-methylphenyl)-N-hydroxymethanimidamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C12H18N2O |
| Molecular weight | 206.28 |
| Biochem/physiol Actions【生化/生理作用】 | HET0016 is a potent and selective inhibitor against cytochrome P450 (CYP450) ω-hydroxylases (human CYP4A11/4A22/4F2/4F3, rat CYP4A1/4A2/4A3/4A8)-mediated 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis (IC50 = 8.9/35 nM using human/rat renal microsomes), exhibiting much reduced potency against epoxyeicosatrienoic acids (EETs) biosynthesis (IC50 = 2.8 μM/rat microsome) or the enzyme activities of CYP2C9/2D6/3A4 and COX (IC50 = 3.3/83.9/71 μM and 2.3 μM). HET0016 is widely employed both in cultures (1-10 μM) and in aminals in vivo (1-10 mg/kg via i.v., i.m., i.p. or s.c.) for probing 20-HETE-dependent physiological and pathological processes. |
产品性质
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CCCCC1=CC=C(C(C)=C1)/N=C/NO |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
