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6-乙酰-7-脱乙酰福斯考灵
Isoforskolin
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4086194 | 5 MG | 968 | |||
| 4086194 | 25 MG | 3500 |
产品别名
64657-21-2
6-乙酰-7-脱乙酰福斯考灵
Isoforskolin
(3R,6S,6aS)-6-(acetyloxy)-3-ethenyldodecahydro-5S,10S,10bS-trihydroxy-3,4aR,7,7,10aR-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
6-Acetyl-7-deacetylforskolin
6β-Acetoxy-1α,7β,9α-trihydroxy-8,13-epoxy-labd-14-en-11-one
Coleonol B
6β-乙酰氧基-1α,7β,9α-三羟基-8,13-环氧-异佛司可林-14-烯-11-酮
异佛司可林
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H34O7 |
| Molecular weight | 410.50 |
| MDL number | MFCD00078929 |
| Biochem/physiol Actions【生化/生理作用】 | Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a rat asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | powder |
| optical activity【旋光性】 | [α]/D -8 to -5°, c = 0.5 in chloroform-d |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMF:H2O (9:1): 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CC(=O)O[C@@H]1[C@H](O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)C13)C=C |
| InChI | 1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1 |
| InChI key | CLOQVZCSBYBUPB-VDCUXWMXSA-N |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H312 |
| Precautionary Statements | P280 - P302 + P352 + P312 - P362 + P364 - P501 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Dermal |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
