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ITH12575
产品别名
1802013-08-6
ITH12575
4,1-Benzothiazepin-2(3H)-one, 7-chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-
7-Chloro-5-(2′-isopropylphenyl)-3,5-dihydro-4,1-benzothiazepin-2-(1H)-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H18ClNOS |
| Molecular weight | 331.86 |
| MDL number | MFCD30720887 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | ITH12575 is apotent and selective inhibitor of mitochondrial Na+/Ca2+ exchanger mNCX with neuroprotective activity. It was shown to reduce Ca2+ efflux from the mitochondria to the cytosol with an EC50 value of 690 nM and was shown to protect against Ca2+ overload and mitigated the neuronal damage in a model of oxidative stress. At higher concentrations ITH12575 also reduced Ca2+ influx through CALHM1, a Ca2+ channel that plays a key role in the neuronal electrical activity. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC(C)C1=C(C2C(C=C(Cl)C=C3)=C3NC(CS2)=O)C=CC=C1 |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
