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LIT-927
产品别名
2172879-52-4
LIT-927
4-(4-Chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)-2(1H)-pyrimidinone
4-(4-Chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)pyrimidin-2(1H)-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H13ClN2O3 |
| Molecular weight | 328.75 |
| MDL number | MFCD31726172 |
| Biochem/physiol Actions【生化/生理作用】 | LIT-927 is an orally active CXCL12 (SDF1) neutraligand (Kd = 267) that selectively neutralizes CXCL12, but not CCL17, CCL22, CCL5, or CCL2 activity in cultures (10 μM LIT-927 against 5 nM chemokine-induced calcium mobilization). LIT-927 reduces eosinophil recruitment in a murine allergic airway hypereosinophilia model in vivo (330 nmol/kg intranasal, 350 nmol/kg ip. or 1400 μmol/kg po.), offering greatly improved oral activity and solubility than Chalcone-4, and exhibiting little side-effects when compared with dexamethasone or CXCR4 antagonist AMD3100. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | yellow to brown |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C1N=C(C=C(N1)C2=CC=C(C(OC)=C2)O)C3=CC=C(C=C3)Cl |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
