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NS3728
产品别名
265646-85-3
NS3728
Endovion
NS 3728
N-(3,5-bis(Trifluoromethyl)phenyl)-N′-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)urea
1-[3,5-bis(Trifluoromethyl)phenyl]-3-[4-bromo-2-(1H-tetrazol-5-yl)phenyl]urea
NS-3728
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H9BrF6N6O |
| Molecular weight | 495.18 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | NS3728 (Endovion) is a di-aryl-urea-based reversible anion channel blocker that is shown to inhibit Ca(2+)-independent Cl- conductance by volume-regulated anion channel (VRAC or VSOAC; IC50 = 400 nM) as well as Ca2+-activated Cl- ccurrent (CaCC) by anoctamin (ANO) in an apparently voltage-dependent manner (IC50 against ANO1 = 2.1 and 0.7 μM at -95 and +50 mV, respectively). NS3728 is reported to be 5.5-times more potent than Tamoxifen against VRAC (IC50 = 0.4 vs. 2.2 μM). |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 10 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
