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SHP1 Inhibitor, TPI-1
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4086392 | 5 MG | 1180 | |||
| 4086392 | 25 MG | 4330 |
产品别名
79756-69-7
SHP1 Inhibitor, TPI-1
2-(2,5-Dichlorophenyl)-2,5-cyclohexadiene-1,4-dione
TPI1
TPI-1
TPI 1
2-(2,5-Dichloro-phenyl)-[1,4]benzoquinone; 2-(2?,5?-Dichlorophenyl)-1,4-benzoquinone
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C12H6Cl2O2 |
| Molecular weight | 253.08 |
| MDL number | MFCD00448731 |
| Biochem/physiol Actions【生化/生理作用】 | TPI-1 is an orally bioavailable, noncytotoxic benzoquinone compound that acts as a potent irreversible inhibitor of SHP-1 (Src homology region 2 domain-containing phosphatase 1) catalytic domain (IC50 ~ 40 nM or 0.01 μg/ml) with selectivity over SHP-2 (IC50 ~ 0.1 μg/ml), MKP1 (IC50 > 1 μg/ml) and CD45. TPI-1 potently induces mouse and human primary IFN-g+ cells both in vitro and in vivo. Effectively inhibits B16 melanoma tumors in mice (1 or 3 mg/kg, s.c., daily) and prolong the survival. TPI-1 is shown to be 50-fold more effective than sodium stibogluconate in cell-based assays and may non-specifically react with cysteine residues. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C1C=CC(C(C2=C(C=CC(Cl)=C2)Cl)=C1)=O |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
