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Takinib
产品别名
1111556-37-6
Takinib
N1-(1-Propyl-1H-benzimidazol-2-yl)-1,3-benzenedicarboxamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H18N4O2 |
| Molecular weight | 322.36 |
| NACRES | NA.77 |
| General description【一般描述】 | Takinib belongs to the aminobenzimidazole class of inhibitors. |
| Application【应用】 | Takinib has been used as an inhibitor of transforming 28 growth factor - β-activated kinase -1 (TAK-1) in human leukemia monocytic THP-1 cells. It may be used as a TAK1 inhibitor in Jurkat cells. |
| Biochem/physiol Actions【生化/生理作用】 | Takinib is a selective inhibitor of TAK1/MAP3K7 kinase, which is a member of the MAP3K family and a key regulator of cell death. It binds in the TAk1 ATPbinding pocket with an IC50 value of 9.5 nM. Takinib selectively induced apoptosis following TNF-α stimulation in rheumatoid arthritis and breast cancer. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CCCN1C2=CC=CC=C2N/C1=N\C(C3=CC(C(N)=O)=CC=C3)=O |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
