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UNC3866 trifluoroacetate salt

产品编号:4086455
规格:≥98% (HPLC)
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40864555 MG1540
408645525 MG5640
产品别名

UNC3866 trifluoroacetate salt

N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-Serine methyl ester trifluoroacetate

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C43H66N6O8
Molecular weight
795.02
Biochem/physiol Actions【生化/生理作用】
UNC3866 inhibits the CBX chromodomains of the Polycomb repressive complex 1 (PRC1), which is involved in transcriptional repression. UNC3866 selectively targets CBX4 and CBX7 most potently, with Kd values of ∼100 nM. The PRC1 chromodomains facilitate PRC1-mediated transcriptional repression by targeting the complex to Trimethyllysine 27 on histone 3 (H3K27me3). UNC3866 antagonizes the methyllysine (Kme) reading function, and has been shown to inhibit the PC3 prostate cancer cell proliferation associated with CBX7 overexpression.
Antagonist of chromodomains CBX4/7 of Polycomb repressive complex 1
产品性质
Assay【测定】
≥98% (HPLC)
form【形式】
lyophilized powder (white)
color【颜色】
white to off-white
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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