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AZD-2098

产品编号:4086589
规格:≥98% (HPLC)
CAS NO:566203-88-1
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40865895 MG1150
408658925 MG4230
产品别名

566203-88-1

AZD-2098

2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide

AZD 2098

2,3-Dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide

AZD2098

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C11H9Cl2N3O3S
Molecular weight
334.18
MDL number
MFCD31382158
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
AZD-2098 is an orally active, potent and selective CCR4 antagonist (pIC50 = 7.8/8.0/8.0/7.6 against CCL22 binding to human/mouse/rat/dog CCR4; inactive toward CXCR1/2 & CCR1/2b/5/7/8 at 10 μM) with little or no activity toward a panel of ∼120 receptors/enzymes. AZD-2098 effectively inhibits chemokine-induced cellular responses in vitro (pIC50 = 7.5 against CCL22-induced calcium influx in hCCR4-expressing CHO cells; pIC50 = 6.3 against CCL17- or CCL22-induced chemotaxis of primary human Th2 cells) and exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats in vivo (Emax = 7.5 μmol/kg p.o.; 1 h before and every 12 h after antigen challenge).
产品性质
Assay【测定】
≥98% (HPLC)
form【形式】
powder
color【颜色】
white to beige
solubility【溶解性】
DMSO: 2 mg/mL, clear
storage temp.【储存温度】
2-8℃
SMILES string
O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=CN=C2OC)=O
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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