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Betrixaban
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产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4086613 | 5 MG | 958 | |||
4086613 | 25 MG | 3360 |
产品别名
330942-05-7
Betrixaban
N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide
MK-4448
PRT-054021
PRT054021
MLN1021
N-(5-Chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C23H22ClN5O3 |
Molecular weight | 451.91 |
MDL number | MFCD16038040 |
Biochem/physiol Actions【生化/生理作用】 | Betrixaban is an orally active, active site-targeting, highly potent and selective factor Xa (fXa) inhibitor (IC50 = 1.5 nM; Ki = 117 pM) with much reduced plasma kallikrein inhibitory activity (IC50 = 6.3 μM) and little potency against thrombin, trypsin, t-PA, aPC or plasmin inhibition (IC50 >10 μM). Betrixaban exhibits good pharmacokinetic properties and anticoagulant efficacy against various thromboembolism (VTE) events in vivo. |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | powder |
color【颜色】 | white to beige |
solubility【溶解性】 | DMSO: 2 mg/mL, clear |
storage temp.【储存温度】 | 2-8℃ |
SMILES string | ClC1=CN=C(C=C1)NC(C2=C(NC(C3=CC=C(C(N(C)C)=N)C=C3)=O)C=CC(OC)=C2)=O |
安全信息
Pictograms【象形图】 | GHS07,GHS08 |
Signal word【警示用语:】 | Warning |
Hazard Statements | H302 - H373 |
Precautionary Statements | P301 + P312 + P330 - P314 |
Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - STOT RE 2 |
Target Organs【靶器官】 | Blood |
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |