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Bindarit

产品编号:4086618
规格:≥98% (HPLC)
CAS NO:130641-38-2
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40866185 MG958
408661825 MG3360
产品别名

130641-38-2

Bindarit

2-((1-Benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid

AF 2838

AF2838

2-Methyl-2-[[1-(phenylmethyl)-1H-indazol-3-yl]methoxy]propanoic acid

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C19H20N2O3
Molecular weight
324.37
MDL number
MFCD00866723
Biochem/physiol Actions【生化/生理作用】
Bindarit is an indazolic derivative with anti-inflammatory efficacy in vitro (150-300 μM) and in animal disease models in vivo (100 mg/kg ip, 50 mg/kg po, or 0.5% in chow; rats & mice). Bindarit selectively inhibits LPS-induced CCL2/MCP-1, CCL7/MCP-3, CCL8/MCP-2 chemokines over CCL3/MIP-1α and IL-8/CXCL8 in human monocytes, while blocking CCL2, but not CCL7 or CCL8, induction in HUVECs, and preventing LPS-induced CCL2 & IL-12β/p40 by inhibiting NFκB activation in murine macrophages (BMDM & Raw 264.7). Bindarit is also reported to exhibit non-competitive inhibiory potency against human monocarboxylate transporter MCT4 (Ki = 30.2 μM) over MCT1 (<40% inhibition at 500 μM).
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
color【颜色】
white to beige
solubility【溶解性】
DMSO: 2 mg/mL, clear
storage temp.【储存温度】
2-8℃
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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