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MK204
产品别名
1959605-73-2
MK204
2-[5-Chloro-2-[[[(2,3,4,5,6-pentabromophenyl)methyl]amino]carbonyl]phenoxy]-acetic acid
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H9Br5ClNO4 |
| Molecular weight | 714.22 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10). AKR1B10 is induced in several cancer types, in particular, hepatocellular carcinoma, and may be involved with drug resistance. MK204 appears to target a distinct AKR1B10 inner specificity pocket not present in the closely related aldose reductase. MK204 had an IC50 value of 80 nM compared to an IC50 value of 21.7 μM for aldose reductase. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 3 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(C1=C(OCC(O)=O)C=C(C=C1)Cl)NCC(C(Br)=C(C(Br)=C2Br)Br)=C2Br |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
