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MSAB
产品别名
173436-66-3
MSAB
Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate
3-[[(4-Methylphenyl)sulfonyl]amino]-benzoic acid methyl ester
WI-21
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H15NO4S |
| Molecular weight | 305.35 |
| PubChem Substance ID【PubChem化学物质编号】 | 329826041 |
| Biochem/physiol Actions【生化/生理作用】 | A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | off-white to purple |
| solubility【溶解性】 | DMSO: 25 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC1=CC=C(S(NC2=CC(C(OC)=O)=CC=C2)(=O)=O)C=C1 |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
