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NCT-503 Inactive Control
产品别名
1914971-16-6
NCT-503 Inactive Control
N-(4,6-Dimethylpyridin-2-yl)-4-(pyridin-4-yl)piperazine-1-carbothioamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H21N5S |
| Molecular weight | 327.45 |
| PubChem Substance ID【PubChem化学物质编号】 | 329826006 |
| NACRES | NA.77 |
| Application【应用】 | NCT-503 Inactive Control has been used as a small molecule inhibitor of phosphoglycerate dehydrogenase in neuroblastoma cells. |
| Biochem/physiol Actions【生化/生理作用】 | NCT-503 Inactive Control is the inactive control probe for NCT-503, which is an inhibitor of phosphoglycerate dehydrogenase (PHGDH), the enzyme that catalyzes the first, rate-limiting step of glucose-derived serine synthesis. NCT-503 Inactive Control has an IC50 value >57 μM for PHGDH. NCT-503 has an IC50 value of 2.5 μM for PHGDH. NCT-503 Inactive Control is water soluble and has good stability, similar to NCT-503. |
| Recommended products【推荐产品】 | The active PHGDH inhibitor, NCT-503, is available from Sigma. To learn more about and purchase NCT-503, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 5 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC1=CC(NC(N2CCN(C3=CC=NC=C3)CC2)=S)=NC(C)=C1 |
| InChI | 1S/C17H21N5S/c1-13-11-14(2)19-16(12-13)20-17(23)22-9-7-21(8-10-22)15-3-5-18-6-4-15/h3-6,11-12H,7-10H2,1-2H3,(H,19,20,23) |
| InChI key | ITLPIAAGIQAGRA-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 |
| Hazard Classifications【危险分类】 | Skin Irrit. 2 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
