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产品别名
6632-09-3
NSC57969
8-Hydroxy-7-(piperidinomethyl)quinoline
7-(Piperidinomethyl)-8-quinolinol
7-(1-Piperidinylmethyl)-8-quinolinol
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H18N2O |
| Molecular weight | 242.32 |
| MDL number | MFCD00469245 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | NSC57969 is a MDR-selective compound that exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines. NSC57969 shows profound toxicity against doxorubicin resistant Brca1-/-;p53-/- spontaneous mouse mammary carcinoma cells. NSC57969 eradicates P-glycoprotein expression in doxorubicin resistant brca1-/-;p53-/- spontaneous mouse mammary carcinoma, and MES-SA/Dx5 cells. However treatment of normal cells (hCMEC/D3 cells) with NSC57969 does not induce loss of Pgp. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 5 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC1=C(N=CC=C2)C2=CC=C1CN3CCCCC3 |
| InChI | 1S/C15H18N2O/c18-15-13(11-17-9-2-1-3-10-17)7-6-12-5-4-8-16-14(12)15/h4-8,18H,1-3,9-11H2 |
| InChI key | WXMFPLZGDXLEMN-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
