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IL-1R Antagonist-CAS 566914-00-9-Calbiochem

产品编号:4087324
规格:The IL-1R Antagonist, also referenced under CAS 566914-00-9, controls the biological activity of IL-1R.
CAS NO:566914-00-9
包装规格:10 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
408732410 MG1710
408732425 MG3240
产品别名

566914-00-9

IL-1R Antagonist-CAS 566914-00-9-Calbiochem

BB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic

基本信息
Empirical Formula【经验(实验)分子式】
C18H26N2O2
Molecular weight
302.41
General description【一般描述】
A cell-permeable, end protected L-valyl derivative of the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
A cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
TIR domain-mediated MyD88/IL1-RI interaction
Warning【警告】
Toxicity: Standard Handling (A)
Reconstitution【重悬】
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes【其他说明】
Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7971.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (HPLC)
form【形式】
oil
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
color【颜色】
colorless
solubility【溶解性】
DMSO: 10 mg/mL
ethanol: soluble
shipped in【运输】
ambient
storage temp.【储存温度】
2-8℃
packaging【包装】
10, 25 mg in Plastic ampoule
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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