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干扰素 α 2A 人
Interferon α 2A human
| 产品编号： | 4087325 |
| 规格： | IFN-α 2A, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture |
| 包装规格： | 10 μG，5 X 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
干扰素 α 2A 人
Interferon α 2A human
基本信息
| NACRES | NA.77 |
| Quality【质量】 | endotoxin tested |
| General description【一般描述】 | The IFNA2 (interferon alpha 2) gene is mapped to human chromosome 9p21.3. It is considered to be a prototypic type I IFN subtype. The encoded protein contains 165 amino acid. Ifna2 protein structure possesses five α-helices, linked by two disulfide bonds. |
| Application【应用】 | Interferon α 2A human has been used to check its antiviral action against chikungunya virus. It has also been used as a control to check the antiviral cytokine induction of Korean red ginseng. |
| Biochem/physiol Actions【生化/生理作用】 | Interferon α 2A (IFN-α 2A) belongs to the type I interferon protein family and is produced by many cell types in response to viral infection. It has antiproliferative and antitumor activities, as well as induction of apoptosis and the inflammatory response. IFN-α 2A enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T cells. IFNA2 is a type 1 interferon which acts as the first line of defense, and offers protection against pathogenic invasion. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution of 1x PBS. |
| Preparation Note【制备说明】 | HumanKine IFN-α 2A, expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 16 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications. |
| Analysis Note【分析说明】 | The specific activity was determined by the dose-dependent proliferation of WISH (heteroploid human amnion cell line) in presence of VSV (vesicular stomatitis virus). |
| Legal Information【法律信息】 | HumanKine is a registered trademark of Proteintech Group, Inc. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| potency【效能】 | ≤0.4 ng/mL EC50 |
| mol wt【分子量】 | monomer 16 kDa (glycosylated) |
| manufacturer/tradename | HumanZyme |
| technique(s) | cell culture | mammalian: suitable |
| impurities【杂质】 | ≤1EU/mg |
| UniProt accession no.【UniProt登记号】 | P01563 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IFNA2(3440) |
| packaging【包装】 | 10 μg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
