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Deracoxib

产品编号:4087358
规格:≥98% (HPLC)
CAS NO:169590-41-4
包装规格:50 MG,100 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
408735850 MG1520
4087358100 MG2870
产品别名

169590-41-4

Deracoxib

4-[3-(Difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl]benzenesulfonamide

SC-046

SC-46

SC-59046

4-[5-(3-Fluoro-4-methoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

基本信息
Empirical Formula【经验(实验)分子式】
C17H14F3N3O3S
Molecular weight
397.37
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
Deracoxib is an orally active cyclooxygenase-2 (COX-2) inhibitor with >48-fold selectivity over COX-1 (IC50 of 203-189 nM against COX-2-dependent PGE2 production vs. IC50 of 9.85-9.96 μM against COX-1-dependent TxB2 production in dog whole blood). Deracoxib is also reported to exhibit inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3) as well as positive modulatory effiacy toward 2-APB-stimulated transient receptor potential vanilloid 3 channel (TRPV3) activity.
产品性质
Assay【测定】
≥98% (HPLC)
form【形式】
powder
color【颜色】
white to brown
solubility【溶解性】
DMSO: 2 mg/mL, clear
storage temp.【储存温度】
room temp
InChI
1S/C17H14F3N3O3S/c1-26-16-7-2-10(8-13(16)18)15-9-14(17(19)20)22-23(15)11-3-5-12(6-4-11)27(21,24)25/h2-9,17H,1H3,(H2,21,24,25)
InChI key
WAZQAZKAZLXFMK-UHFFFAOYSA-N
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H302
Precautionary Statements
P301 + P312 + P330
Hazard Classifications【危险分类】
Acute Tox. 4 Oral
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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