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产品别名
Anti-mGluR4 Antibody
glutamate metabotropic receptor 4, glutamate receptor, metabotropic 4
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. |
| Specificity【特异性】 | Reactivity with other species has not been determined. Cat. # AB15097 recognizes mGluR4 (GRM4). |
| Immunogen【免疫原】 | Recombinant Protein. |
| Application【应用】 | This Anti-mGluR4 Antibody is validated for use in WB for the detection of mGluR4. Research Category Neuroscience Research Sub Category Neurotransmitters & Receptors |
| Quality【质量】 | Western Blot: Mouse Brain Lysate. |
| Physical form【外形】 | Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. Format: Purified Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control Mouse Brain Lysate. |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | mouse, rat |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_001013403.1 |
| UniProt accession no.【UniProt登记号】 | Q68EF4 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~101 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8ºC from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
